Hi Pradeep,
Restarting fixing the issue temporarily is the catch over here. Also check the ENV variables of the OS level users.
Is it an domain installation? If it so maybe after restart updating the domain profiles causing some issues.
Can you ask your windows team to analyze the event viewer and other OS related logs?
Also you can check the trans directory permission.
As a worst case scenario you can reconfigure the STMS configuration and check.
Regards,
Raja. G